Reconstruction of input functions from a dynamic PET image with sequential administration of ¹⁵O₂ and [Formula: see text] for noninvasive and ultra-rapid measurement of CBF, OEF, and CMRO₂.

ABSTRACT: CBF, OEF, and CMRO₂ images can be quantitatively assessed using PET. Their image calculation requires arterial input functions, which require invasive procedure. The aim of the present study was to develop a non-invasive approach with image-derived input functions (IDIFs) using an image from an ultra-rapid O₂ and C¹⁵O₂ protocol. Our technique consists of using a formula to express the input using tissue curve with rate constants. For multiple tissue curves, the rate constants were estimated so as to minimize the differences of the inputs using the multiple tissue curves. The estimated rates were used to express the inputs and the mean of the estimated inputs was used as an IDIF. The method was tested in human subjects ( n = 24). The estimated IDI

SUBMITTER: Kudomi N 

PROVIDER: S-EPMC5987943 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature