C-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4⁺ T cells.

ABSTRACT: The transcription factor c-Maf induces the anti-inflammatory cytokine IL-10 in CD4⁺ T cells in vitro. However, the global effects of c-Maf on diverse immune responses in vivo are unknown. Here we found that c-Maf regulated IL-10 production in CD4⁺ T cells in disease models involving the T_H1 subset of helper T cells (malaria), T_H2 cells (allergy) and T_H17 cells (autoimmunity) in vivo. Although mice with c-Maf deficiency targeted to T cells showed greater pathology in T_H1 and T_H2 responses, T_H17 cell-mediated pathology was reduced in this context, with an accompanying decrease in T_H17 cells and increase in Foxp3⁺ regulatory T cells. Bivariate genomic footprinting elucidated the c-Maf

SUBMITTER: Gabrysova L 

PROVIDER: S-EPMC5988041 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature