Evaluation of person-level heterogeneity of treatment effects in published multiperson N-of-1 studies: systematic review and reanalysis.

ABSTRACT:

Objective

Individual patients with the same condition may respond differently to similar treatments. Our aim is to summarise the reporting of person-level heterogeneity of treatment effects (HTE) in multiperson N-of-1 studies and to examine the evidence for person-level HTE through reanalysis.

Study design

Systematic review and reanalysis of multiperson N-of-1 studies.

Data sources

Medline, Cochrane Controlled Trials, EMBASE, Web of Science and review of references through August 2017 for N-of-1 studies published in English.

Study selection

N-of-1 studies of pharmacological interventions with at least two subjects.

Data synthesis

Citation screening and data extractions were performed in duplicate. We performed statistical reanalysis testing for person-le

SUBMITTER: Raman G 

PROVIDER: S-EPMC5988083 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature