Putative mechanisms Underlying Myocardial infarction onset and Emotions (PUME): a randomised controlled study protocol.

ABSTRACT:

Introduction

The experience of negative emotions (eg, anger, anxiety and sadness) is associated with an increased short-term risk of incident cardiovascular disease (CVD) events, independent of traditional CVD risk factors. Impairment in endothelial function is one possible biological mechanism which may explain the association between negative emotions and incident CVD events. This laboratory-based, single-blind, randomised controlled experimental study aims to investigate the impact of induced negative emotions including anger, anxiety and sadness on endothelial function.

Methods and analysis

In a between-subjects design, 280 healthy participants are randomised to one of four experimental negative emotion inductions: anger, anxiety, sadness or a neutral condition. Endothel

SUBMITTER: Ensari I 

PROVIDER: S-EPMC5988091 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature