Risk factors and determinants of carotid intima-media thickness in children: protocol for a systematic review and meta-analysis.

ABSTRACT:

Introduction

Carotid intima-media thickness (CIMT) is a surrogate marker of atherosclerosis that is measured in adults and children to better understand the natural history of cardiovascular disease (CVD). In adults, CIMT is predictive of myocardial infarction and stroke. In children and adolescents, CIMT is used to assess vascular changes in the presence of CVD risk factors (obesity, hypertension, smoking, etc) or clinical conditions associated with a high risk for premature CVD. However, there is no comprehensive overview, in a life-course epidemiology perspective, of the risk factors and determinants of CIMT in children. It is also important to evaluate between-study differences in CIMT measurement methods and take them into consideration when drawing conclusions. Our objective

SUBMITTER: Epure AM 

PROVIDER: S-EPMC5988176 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature