The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex trans-[Pt(NH₃)₂(phenanthridine)Cl]NO₃.

ABSTRACT: A trans-DDP based monofunctional phenanthridine Pt(ii) complex was synthesized and characterized. Its anticancer activity was studied in vitro on a panel of human cancer cell lines and mouse intestinal cancer organoids. This complex displays significant antitumor properties, with a different spectrum of activity than that of classic bifunctional cross-linking agents like cisplatin.

SUBMITTER: Zhou W 

PROVIDER: S-EPMC5988251 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature