Transcriptome alterations of vascular smooth muscle cells in aortic wall of myocardial infarction patients.

ABSTRACT: This article contains further data and information from our published manuscript [1]. We aim to identify significant transcriptome alterations of vascular smooth muscle cells (VSMCs) in the aortic wall of myocardial infarction (MI) patients. Microarray gene analysis was applied to evaluate VSMCs of MI and non-MI patients. Prediction Analysis of Microarray (PAM) identified genes that significantly discriminated the two groups of samples. Incorporation of gene ontology (GO) identified a VSMCs-associated classifier that discriminated between the two groups of samples. Mass spectrometry-based iTRAQ analysis revealed proteins significantly differentiating these two groups of samples. Ingenuity Pathway Analysis (IPA) revealed top pathways associated with hypoxia signaling in cardiovascular syste

SUBMITTER: Wongsurawat T 

PROVIDER: S-EPMC5988399 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature