Phase I study of nab-paclitaxel, gemcitabine, and bevacizumab in patients with advanced cancers.

ABSTRACT:

Background

We performed a phase I modified 3 + 3 dose escalation study to evaluate the safety and activity of bevacizumab plus gemcitabine and nab-paclitaxel in patients with advanced solid tumours.

Methods

Patients were given fixed dose gemcitabine plus increasing doses of nab-paclitaxel and bevacizumab. Toxicity, response, and association with VEGF polymorphism was analysed.

Results

The study enrolled 110 patients who had undergone a median of 3 prior lines of therapy. The median age was 60 years (range, 17-85 years), and 55 patients (50%) had gemcitabine-refractory disease. We observed 3 dose-limiting toxicities during dose escalation and 3 DLTs in expansion cohorts. Dose escalation to 150 mg/m² nab-paclitaxel and 15 mg/kg bevacizumab with 1000 mg/m

SUBMITTER: Sen S 

PROVIDER: S-EPMC5988803 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature