Rodent vertical sleeve gastrectomy alters maternal immune health and fetoplacental development.

ABSTRACT: Bariatric surgery is increasingly employed to improve fertility and reduce obesity-related co-morbidities in obese women. Surgical weight loss not only improves the chance of conception but reduces the risk of pregnancy complications including pre-eclampsia, gestational diabetes, and macrosomia. However, bariatric procedures increase the incidence of intrauterine growth restriction (IUGR), fetal demise, thromboembolism, and other gestational disorders. Using our rodent model of vertical sleeve gastrectomy (VSG), we tested the hypothesis that VSG in diet-induced, obese dams would cause immune and placental structural abnormalities that may be responsible for fetal demise during pregnancy. VSG dams studied on gestational day (G) 19 had reduced circulating T-cell (CD3⁺ and CD8

SUBMITTER: Spann RA 

PROVIDER: S-EPMC5989318 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature