BgTEP: An Antiprotease Involved in Innate Immune Sensing in Biomphalaria glabrata.

ABSTRACT: Insect thioester-containing protein (iTEP) is the most recently defined group among the thioester-containing protein (TEP) superfamily. TEPs are key components of the immune system, and iTEPs from flies and mosquitoes were shown to be major immune weapons. Initially characterized from insects, TEP genes homologous to iTEP were further described from several other invertebrates including arthropods, cniderians, and mollusks albeit with few functional characterizations. In the freshwater snail Biomphalaria glabrata, a vector of the schistosomiasis disease, the presence of a TEP protein (BgTEP) was previously described in a well-defined immune complex involving snail lectins (fibrinogen-related proteins) and schistosome parasite mucins (SmPoMuc). To investigate the potential role of Bg

SUBMITTER: Portet A 

PROVIDER: S-EPMC5989330 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature