A candidate gene identification strategy utilizing mouse to human big-data mining: "3R-tenet" in COPD genetic research.

ABSTRACT:

Background

Early life impairments leading to lower lung function by adulthood are considered as risk factors for chronic obstructive pulmonary disease (COPD). Recently, we compared the lung transcriptomic profile between two mouse strains with extreme total lung capacities to identify plausible pulmonary function determining genes using microarray analysis (GSE80078). Advancement of high-throughput techniques like deep sequencing (eg. RNA-seq) and microarray have resulted in an explosion of genomic data in the online public repositories which however remains under-exploited. Strategic curation of publicly available genomic data with a mouse-human translational approach can effectively implement "3R- Tenet" by reducing screening experiments with animals and performing mechanistic st

SUBMITTER: Vishweswaraiah S 

PROVIDER: S-EPMC5989378 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature