Collective interaction effects associated with mammalian behavioral traits reveal genetic factors connecting fear and hemostasis.

ABSTRACT:

Background

Investigation of the genetic architectures that influence the behavioral traits of animals can provide important insights into human neuropsychiatric phenotypes. These traits, however, are often highly polygenic, with individual loci contributing only small effects to the overall association. The polygenicity makes it challenging to explain, for example, the widely observed comorbidity between stress and cardiac disease.

Methods

We present an algorithm for inferring the collective association of a large number of interacting gene variants with a quantitative trait. Using simulated data, we demonstrate that by taking into account the non-uniform distribution of genotypes within a cohort, we can achieve greater power than regression-based methods for high-dimensiona

SUBMITTER: Woo HJ 

PROVIDER: S-EPMC5989392 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature