Metabolomics approach by ¹H NMR spectroscopy of serum reveals progression axes for asymptomatic hyperuricemia and gout.

ABSTRACT:

Background

Gout is a metabolic disease and is the most common form of inflammatory arthritis affecting men. However, the pathogenesis of gout is still uncertain, and novel biomarkers are needed for early prediction and diagnosis of gout. The aim of this study was to develop a systemic metabolic profile of patients with asymptomatic hyperuricemia (HUA) and gout by using a metabolomics approach, and find potential pathophysiological mechanisms of and markers of predisposition to gout.

Methods

Serum samples were collected from 149 subjects, including 50 patients with HUA, 49 patients with gout and 50 healthy controls. ¹H nuclear magnetic resonance (NMR) spectroscopy combined with principal components analysis and orthogonal partial least squares-discriminant analysis

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5989453 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature