Disease Severity Dependence of the Longitudinal Association Between CT Lung Density and Lung Function in Smokers.

ABSTRACT:

Background

In smokers, the lung parenchyma is characterized by inflammation and emphysema, processes that can result in local gain and loss of lung tissue. CT measures of lung density might reflect lung tissue changes; however, longitudinal data regarding the effects of CT lung tissue on FEV₁ in smokers with and without COPD are scarce.

Methods

The 15th percentile of CT lung density was obtained from the scans of 3,390 smokers who completed baseline and 5-year follow-up of the Genetic Epidemiology of COPD (COPDGene) study visits. The longitudinal relationship between total lung capacity-adjusted lung density (TLC-PD15) and FEV₁ was assessed by using multivariable mixed models. Separate models were performed in smokers at risk, smokers with preserved rat

SUBMITTER: Diaz AA 

PROVIDER: S-EPMC5989632 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature