Responders and non-responders to influenza vaccination: A DNA methylation approach on blood cells.

ABSTRACT: Several evidences indicate that aging negatively affects the effectiveness of influenza vaccination. Although it is well established that immunosenescence has an important role in vaccination response, the molecular pathways underlying this process are largely unknown. Given the importance of epigenetic remodeling in aging, here we analyzed the relationship between responsiveness to influenza vaccination and DNA methylation profiles in healthy subjects of different ages. Peripheral blood mononuclear cells were collected from 44 subjects (age range: 19-90 years old) immediately before influenza vaccination. Subjects were subsequently classified as responders or non-responders according to hemagglutination inhibition assay 4-6 weeks after the vaccination. Baseline whole genome DNA methylatio

SUBMITTER: Gensous N 

PROVIDER: S-EPMC5989724 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature