Caloric restriction promotes rapid expansion and long-lasting increase of Lactobacillus in the rat fecal microbiota.

ABSTRACT: Previous studies indicated that caloric restricted diet enables to lower significantly the risk of cardiovascular and metabolic diseases. In experimental animal models, life-long lasting caloric restriction (CR) was demonstrated to induce changes of the intestinal microbiota composition, regardless of fat content and/or exercise. To explore the potential impact of short and long-term CR treatment on the gut microbiota, we conducted an analysis of fecal microbiota composition in young and adult Fisher 344 rats treated with a low fat feed under ad libitum (AL) or CR conditions (70%). We report here significant changes of the rat fecal microbiota that arise rapidly in young growing animals after short-term administration of a CR diet. In particular, Lactobacillus increased significantly after

SUBMITTER: Fraumene C 

PROVIDER: S-EPMC5989789 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature