Collagen-induced arthritis as an animal model of rheumatoid cachexia.

ABSTRACT:

Background

Rheumatoid arthritis is characterized by chronic polyarticular synovitis and presents systemic changes that impact quality of life, such as impaired muscle function, seen in up to 66% of the patients. This can progress to severely debilitating state known as rheumatoid cachexia-without loss of fat mass and body weight-for which there is little consensus in terms of diagnosis or treatment. This study aims to evaluate whether the collagen-induced arthritis (CIA) animal model also develops clinical and functional features characteristic of rheumatoid cachexia.

Methods

Male DBA1/J mice were randomly divided into 2 groups: healthy animals (CO, n = 11) and CIA animals (n = 13). The clinical score and edema size, animal weight and food intake, free exploratory locomotion

SUBMITTER: Alabarse PVG 

PROVIDER: S-EPMC5989855 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature