Establishment of the nasal microbiota in the first 18 months of life: Correlation with early-onset rhinitis and wheezing.

ABSTRACT:

Background

Dynamic establishment of the nasal microbiota in early life influences local mucosal immune responses and susceptibility to childhood respiratory disorders.

Objective

The aim of this case-control study was to monitor, evaluate, and compare development of the nasal microbiota of infants with rhinitis and wheeze in the first 18 months of life with those of healthy control subjects.

Methods

Anterior nasal swabs of 122 subjects belonging to the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) birth cohort were collected longitudinally over 7 time points in the first 18 months of life. Nasal microbiota signatures were analyzed by using 16S rRNA multiplexed pair-end sequencing from 3 clinical groups: (1) patients with rhinitis alone (n = 28), (2) patients

SUBMITTER: Ta LDH 

PROVIDER: S-EPMC5989928 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature