Altered interoceptive activation before, during, and after aversive breathing load in women remitted from anorexia nervosa.

ABSTRACT:

Background

The neural mechanisms of anorexia nervosa (AN), a severe and chronic psychiatric illness, are still poorly understood. Altered body state processing, or interoception, has been documented in AN, and disturbances in aversive interoception may contribute to distorted body perception, extreme dietary restriction, and anxiety. As prior data implicate a potential mismatch between interoceptive expectation and experience in AN, we examined whether AN is associated with altered brain activation before, during, and after an unpleasant interoceptive state change.

Methods

Adult women remitted from AN (RAN; n = 17) and healthy control women (CW; n = 25) underwent functional magnetic resonance imaging during an inspiratory breathing load paradigm.

Results

During stimul

SUBMITTER: Berner LA 

PROVIDER: S-EPMC5990016 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature