Development of Posterior Medial Frontal Cortex Function in Pediatric Obsessive-Compulsive Disorder.

ABSTRACT:

Objective

Abnormal engagement of the posterior medial frontal cortex (pMFC) occurs during performance monitoring in obsessive-compulsive disorder (OCD), including in pediatric patients. Yet, the development of pMFC function in OCD-affected youth remains poorly understood.

Method

A total of 69 patients with pediatric OCD and 72 healthy controls (HC), 8 to 19 years of age, were scanned during the Multisource Interference Task (MSIT). The effects of group, age, performance, and interactions on pMFC response to errors and interference were tested in the region of interest [ROI]) and whole-brain analyses. Secondary analyses considered bilateral anterior insula/frontal operculum (aI/fO), given the contribution of these regions with pMFC to a cingulo-opercular network (CON) for tas

SUBMITTER: Fitzgerald KD 

PROVIDER: S-EPMC5990044 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature