Evaluating the Use of Bortezomib and Eculizumab in Desensitization of Transplant Patients.

ABSTRACT: Objective: To systematically review the existing literature concerning the utilization of bortezomib and eculizumab to determine if there is enough evidence to warrant their routine use in desensitization protocols for high-risk transplant candidates. Data Sources: PubMed, Google Scholar, and ClinicalTrials.gov were searched using the terms bortezomib, eculizumab, desensitization, transplant, highly-sensitized, pre-sensitized, and antibody-mediated rejection (AMR). The articles included were published between January 2009 and August 2012. Study Selection and Data Extraction: All English-language articles involving human subjects were assessed for inclusion. The search included articles evaluating the use of these agents in desensitization and the prevention of AMR, but

SUBMITTER: Kwiatkowski M 

PROVIDER: S-EPMC5990132 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature