Genomic mechanisms of fatigue in survivors of colorectal cancer.

ABSTRACT:

Background

Many cancer survivors experience fatigue as a nagging symptom lasting years after treatment. To learn of the relevant biological pathways involved in fatigue among cancer survivors, the authors tested for an association between fatigue levels and leukocyte gene expression profiles and determined the specific mediating immune cell types.

Methods

A sample of 89 Hispanic/Latino adults aged 60.5 years, 62% of whom were male, who were diagnosed with colorectal cancer and were 2.9 years since diagnosis provided blood for transcriptome profiling and completed a validated measure of fatigue (Multidimensional Fatigue Symptom Inventory-Short Form). The authors applied genome-wide transcriptional profiling of leukocyte RNA to identify gene expression activity associated with

SUBMITTER: Black DS 

PROVIDER: S-EPMC5990448 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature