Longitudinal cognitive biomarkers predicting symptom onset in presymptomatic frontotemporal dementia.

ABSTRACT:

Introduction

We performed 4-year follow-up neuropsychological assessment to investigate cognitive decline and the prognostic abilities from presymptomatic to symptomatic familial frontotemporal dementia (FTD).

Methods

Presymptomatic MAPT (n = 15) and GRN mutation carriers (n = 31), and healthy controls (n = 39) underwent neuropsychological assessment every 2 years. Eight mutation carriers (5 MAPT, 3 GRN) became symptomatic. We investigated cognitive decline with multilevel regression modeling; the prognostic performance was assessed with ROC analyses and stepwise logistic regression.

Results

MAPT converters declined on language, attention, executive function, social cognition, and memory, and GRN converters declined on attention and executive function (p < 0.05). Cogn

SUBMITTER: Jiskoot LC 

PROVIDER: S-EPMC5990575 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature