Integrin β1 Optimizes Diabetogenic T Cell Migration and Function in the Pancreas.

ABSTRACT: T cell search behavior is dictated by their need to encounter their specific antigen to eliminate target cells. However, mechanisms controlling effector T cell motility are highly tissue-dependent. Specifically, how diabetogenic T cells encounter their target beta cells in dispersed islets throughout the pancreas (PA) during autoimmune diabetes remains unclear. Using intra-vital 2-photon microscopy in a mouse model of diabetes, we found that CXCR3 chemokine downregulated CD8⁺ T cell motility specifically within islets, promoting effector cell confinement to their target sites. By contrast, T cell velocity and directionality in the exocrine tissue were enhanced along blood vessels and extracellular matrix fibers. This guided migration implicated integrin-dependent interactions, s

SUBMITTER: Espinosa-Carrasco G 

PROVIDER: S-EPMC5990596 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature