Costimulatory Function of Cd58/Cd2 Interaction in Adaptive Humoral Immunity in a Zebrafish Model.

ABSTRACT: CD58 and CD2 have long been known as a pair of reciprocal adhesion molecules involved in the immune modulations of CD8⁺ T and NK-mediated cellular immunity in humans and several other mammals. However, the functional roles of CD58 and CD2 in CD4⁺ T-mediated adaptive humoral immunity remain poorly defined. Moreover, the current functional observations of CD58 and CD2 were mainly acquired from in vitro assays, and in vivo investigation is greatly limited due to the absence of a Cd58 homology in murine models. In this study, we identified cd58 and cd2 homologs from the model species zebrafish (Danio rerio). These two molecules share conserved structural features to their mammalian counterparts. Functionally, cd58 and cd

SUBMITTER: Shao T 

PROVIDER: S-EPMC5990624 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature