Development and validation of an MRI-based model to predict response to chemoradiotherapy for rectal cancer.

ABSTRACT:

Background and purpose

To safely implement organ preserving treatment strategies for patients with rectal cancer, well-considered selection of patients with favourable response is needed. In this study, we develop and validate an MRI-based response predicting model.

Methods

A multivariate model using T2-volumetric and DWI parameters before and 6 weeks after chemoradiation (CRT) was developed using a cohort of 85 rectal cancer patients and validated in an external cohort of 55 patients that underwent preoperative CRT.

Results

Twenty-two patients (26%) achieved ypT0-1N0 response in the development cohort versus 13 patients (24%) in the validation cohort. Two T2-volumetric parameters (ΔVolume% and Sphere_post) and two DWI parameters (ADC_avg_post and ADCratio_avg) were r

SUBMITTER: Bulens P 

PROVIDER: S-EPMC5990635 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature