Collective cell migration without proliferation: density determines cell velocity and wave velocity.

ABSTRACT: Collective cell migration contributes to embryogenesis, wound healing and tumour metastasis. Cell monolayer migration experiments help in understanding what determines the movement of cells far from the leading edge. Inhibiting cell proliferation limits cell density increase and prevents jamming; we observe long-duration migration and quantify space-time characteristics of the velocity profile over large length scales and time scales. Velocity waves propagate backwards and their frequency depends only on cell density at the moving front. Both cell average velocity and wave velocity increase linearly with the cell effective radius regardless of the distance to the front. Inhibiting lamellipodia decreases cell velocity while waves either disappear or have a lower frequency. Our model combine

SUBMITTER: Tlili S 

PROVIDER: S-EPMC5990758 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature