Epigenetic marks of in utero exposure to gestational diabetes and childhood adiposity outcomes: the EPOCH study.

ABSTRACT: AIMS:To identify gestational diabetes mellitus exposure-associated DNA methylation changes and assess whether such changes are also associated with adiposity-related outcomes. METHODS:We performed an epigenome-wide association analysis, using Illumina 450k methylation arrays, on whole blood collected, on average, at 10.5 years of age from 81 gestational diabetes-exposed and 81 unexposed offspring enrolled in the EPOCH (Exploring Perinatal Outcomes in Children) study, and on the cord blood of 31 gestational diabetes-exposed and 64 unexposed offspring enrolled in the Colorado Healthy Start cohort. Validation was performed by pyrosequencing. RESULTS:We identified 98 differentially methylated positions associated with gestational diabetes exposure at a false discovery rate of <10% in periphera

SUBMITTER: Yang IV 

PROVIDER: S-EPMC5991099 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature