Bioinformatics characterization of envelope glycoprotein from Kyasanur Forest disease virus.

ABSTRACT:

Background & objectives

Kyasanur Forest disease (KFD) is a febrile illness characterized by haemorrhages and caused by KFD virus (KFDV), which belongs to the Flaviviridae family. It is reported to be an endemic disease in Shimoga district of Karnataka State, India, especially in forested and adjoining areas. Several outbreaks have been reported in newer areas, which raised queries regarding the changing nature of structural proteins if any. The objective of the study was to investigate amino acid composition and antigenic variability if any, among the envelope glycoprotein (E-proteins) from old and new strains of KFDV.

Methods

Bioinformatic tools and techniques were used to predict B-cell epitopes and three-dimensional structures and to compare envelope glycoprotein (E-prote

SUBMITTER: Shil P 

PROVIDER: S-EPMC5991130 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature