A single-cell epigenetic model for paternal psychological stress-induced transgenerational reprogramming in offspring.

ABSTRACT: Experimental evidence shows that parental psychological stress affects the long-term health of offspring in an inheritable fashion. Although epigenetic mechanisms, including DNA methylation, miRNA, and histone modifications, are involved in transgenerational programming, the underlining mechanisms of transgenerational inheritance remain unsolved. Here, we present a single-cell-based computational model for transgenerational inheritance for investigating the long-term dynamics of phenotype changes in response to parental stress. The model is based on a recent study that has identified the imprinted sperm gene Sfmbt2 as a key target, and incorporates crosstalks among drastically different time scales in mammalian development, including DNA methylation, transcription, cell division, and popul

SUBMITTER: Lei J 

PROVIDER: S-EPMC5991201 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature