Local and Global Spatial Organization of Interaural Level Difference and Frequency Preferences in Auditory Cortex.

ABSTRACT: Despite decades of microelectrode recordings, fundamental questions remain about how auditory cortex represents sound-source location. Here, we used in vivo 2-photon calcium imaging to measure the sensitivity of layer II/III neurons in mouse primary auditory cortex (A1) to interaural level differences (ILDs), the principal spatial cue in this species. Although most ILD-sensitive neurons preferred ILDs favoring the contralateral ear, neurons with either midline or ipsilateral preferences were also present. An opponent-channel decoder accurately classified ILDs using the difference in responses between populations of neurons that preferred contralateral-ear-greater and ipsilateral-ear-greater stimuli. We also examined the spatial organization of binaural tuning properties across the imaged n

SUBMITTER: Panniello M 

PROVIDER: S-EPMC5991210 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature