Preconception Maternal Iodine Status Is Positively Associated with IQ but Not with Measures of Executive Function in Childhood.

ABSTRACT:

Background

Adverse effects of severe maternal iodine deficiency in pregnancy on fetal brain development are well-established, but the effects of milder deficiency are uncertain. Most studies examine iodine status in pregnancy; less is known about iodine nutrition before conception.

Objective

We examined relations between maternal preconception iodine status and offspring cognitive function, within a prospective mother-offspring cohort.

Methods

Maternal iodine status was assessed through the use of the ratio of iodine:creatinine concentrations (I/Cr) in spot urine samples [median (IQR) period before conception 3.3 y (2.2-4.7 y)]. Childhood cognitive function was assessed at age 6-7 y. Full-scale IQ was assessed via the Wechsler Abbreviated Scale of Intelligence, and ex

SUBMITTER: Robinson SM 

PROVIDER: S-EPMC5991217 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature