Nicotine Increases Activation to Anticipatory Valence Cues in Anterior Insula and Striatum.

ABSTRACT: Introduction:Smoking is associated with significant morbidity and mortality. Understanding the neurobiology of the rewarding effects of nicotine promises to aid treatment development for nicotine dependence. Through its actions on mesolimbic dopaminergic systems, nicotine engenders enhanced responses to drug-related cues signaling rewards, a mechanism hypothesized to underlie the development and maintenance of nicotine addiction. Methods:We evaluated the effects of acute nicotine on neural responses to anticipatory cues signaling (nondrug) monetary reward or loss among 11 nonsmokers who had no prior history of tobacco smoking. In a double-blind, crossover design, participants completed study procedures while wearing nicotine or placebo patches at least 1 week apart. In each drug condition,

SUBMITTER: Moran LV 

PROVIDER: S-EPMC5991218 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature