Pro-inflammatory AGE-RAGE signaling is activated during arousal from hibernation in ground squirrel adipose.

ABSTRACT:

Background

Inflammation is generally suppressed during hibernation, but select tissues (e.g. lung) have been shown to activate both antioxidant and pro-inflammatory pathways, particularly during arousal from torpor when breathing rates increase and oxidative metabolism fueling the rewarming process produces more reactive oxygen species. Brown and white adipose tissues are now understood to be major hubs for the regulation of immune and inflammatory responses, yet how these potentially damaging processes are regulated by fat tissues during hibernation has hardly been studied. The advanced glycation end-product receptor (RAGE) can induce pro-inflammatory responses when bound by AGEs (which are glycated and oxidized proteins, lipids, or nucleic acids) or damage associated molecular pa

SUBMITTER: Logan SM 

PROVIDER: S-EPMC5991297 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature