Cytotoxicity and antimicrobial action of selected phytochemicals against planktonic and sessile Streptococcus mutans.

ABSTRACT:

Background

Dental caries remains the most prevalent and costly oral infectious disease worldwide, encouraging the search for new and more effective antimicrobials. Therefore, the aim of this work was to study the antimicrobial action of selected phytochemicals (eugenol, citronellol, sabinene hydrate, trans-cinnamaldehyde, terpineol and cinnamic acid) against Streptococcus mutans in planktonic and biofilm states as well as the cytotoxicity of these compounds.

Methods

The antibacterial activity of the selected compounds was evaluated by the determination of the minimal bactericidal concentration. The resazurin assay was used to assess the metabolic activity of sessile S. mutans. The cytotoxicity was determined using a fibroblast cell line.

Results

Among th

SUBMITTER: Ribeiro M 

PROVIDER: S-EPMC5991298 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature