Lung size mismatch in bilateral lung transplantation is associated with allograft function and bronchiolitis obliterans syndrome.

ABSTRACT:

Background

Size mismatch between donor lungs and a recipient thorax could affect the major determinants of maximal expiratory airflow: airway resistance, propensity of airways to collapse, and lung elastic recoil.

Methods

A retrospective review of 159 adults who received bilateral lung transplants was performed. The predicted total lung capacity (pTLC) for donors and recipients was calculated based on sex and height. Size matching was represented using the following formula: pTLC ratio = donor pTLC / recipient pTLC. Patients were grouped according to those with a pTLC ratio > 1.0 (oversized) or those with a pTLC ratio ≤ 1.0 (undersized). Allograft function was analyzed in relation to the pTLC ratio and to recipient and donor predicted function.

Results

The 96 patients

SUBMITTER: Eberlein M 

PROVIDER: S-EPMC5991546 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature