MiRNA-regulated transcription associated with mouse strains predisposed to hypnotic effects of ethanol.

ABSTRACT:

Introduction

Studying innate sensitivity to ethanol can be an important first step toward understanding alcohol use disorders. In brain, we investigated transcripts, with evidence of miRNA modulation related to a predisposition to the hypnotic effect of ethanol, as measured by loss of righting reflex (LORR).

Methods

Expression of miRNAs (12 samples) and expression of mRNAs (353 samples) in brain were independently analyzed for an association with LORR in mice from the LXS recombinant inbred panel gathered across several small studies. These results were then integrated via a meta-analysis of miRNA-mRNA target pairs identified in miRNA-target interaction databases.

Results

We found 112 significant miRNA-mRNA pairs where a large majority of miRNAs and mRNAs were highly

SUBMITTER: Vestal B 

PROVIDER: S-EPMC5991579 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature