Altered resting-state hippocampal and caudate functional networks in patients with obstructive sleep apnea.

ABSTRACT:

Introduction

Brain structural injury and metabolic deficits in the hippocampus and caudate nuclei may contribute to cognitive and emotional deficits found in obstructive sleep apnea (OSA) patients. If such contributions exist, resting-state interactions of these subcortical sites with cortical areas mediating affective symptoms and cognition should be disturbed. Our aim was to examine resting-state functional connectivity (FC) of the hippocampus and caudate to other brain areas in OSA relative to control subjects, and to relate these changes to mood and neuropsychological scores.

Methods

We acquired resting-state functional magnetic resonance imaging (fMRI) data from 70 OSA and 89 healthy controls using a 3.0-Tesla magnetic resonance imaging scanner, and assessed psychologic

SUBMITTER: Song X 

PROVIDER: S-EPMC5991585 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature