Bioengineered lungs generated from human iPSCs-derived epithelial cells on native extracellular matrix.

ABSTRACT: The development of an alternative source for donor lungs would change the paradigm of lung transplantation. Recent studies have demonstrated the potential feasibility of using decellularized lungs as scaffolds for lung tissue regeneration and subsequent implantation. However, finding a reliable cell source and the ability to scale up for recellularization of the lung scaffold still remain significant challenges. To explore the possibility of regeneration of human lung tissue from stem cells in vitro, populations of lung progenitor cells were generated from human iPSCs. To explore the feasibility of producing engineered lungs from stem cells, we repopulated decellularized human lung and rat lungs with iPSC-derived epithelial progenitor cells. The iPSCs-derived epithelial progenitor cells li

SUBMITTER: Ghaedi M 

PROVIDER: S-EPMC5991621 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature