Ontology highlight
ABSTRACT:
SUBMITTER: Lundquist MR
PROVIDER: S-EPMC5991623 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Molecular cell 20180501 3
While the majority of phosphatidylinositol-4, 5-bisphosphate (PI-4, 5-P<sub>2</sub>) in mammalian cells is generated by the conversion of phosphatidylinositol-4-phosphate (PI-4-P) to PI-4, 5-P<sub>2</sub>, a small fraction can be made by phosphorylating phosphatidylinositol-5-phosphate (PI-5-P). The physiological relevance of this second pathway is not clear. Here, we show that deletion of the genes encoding the two most active enzymes in this pathway, Pip4k2a and Pip4k2b, in the liver of mice c ...[more]