Meta-analyses of IL1A polymorphisms and the risk of several autoimmune diseases published in databases.

ABSTRACT:

Background

Based on published data, we aimed to quantitatively elucidate the possible genetic influence of rs17561 G/T and rs1800587 C/T polymorphisms of the IL1A (interleukin 1 alpha) gene in the susceptibility to several autoimmune diseases.

Methods

A series of meta-analyses were carried out. After database searching, we utilized our inclusion/exclusion criteria to screen and include the eligible studies. Passociation (P value of association test), Bonferroni-corrected Passociation value; false discovery rate (FDR)-corrected Passociation, ORs (odd ratios), and 95% CI (confidence interval) were generated to assess the magnitudes of genetic relationships.

Results

A total of 35 eligible articles were included. Pooled analysis data of both rs17561 G/T and rs1800587 C/T

SUBMITTER: Su H 

PROVIDER: S-EPMC5991676 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature