Components of day-to-day variability of cerebral perfusion measurements - Analysis of phase contrast mapping magnetic resonance imaging measurements in healthy volunteers.

ABSTRACT:

Purpose

The aim of the study was to investigate the components of day-to-day variability of repeated phase contrast mapping (PCM) magnetic resonance imaging measurements of global cerebral blood flow (gCBF).

Materials and methods

Two dataset were analyzed. In Dataset 1 duplicated PCM measurements of total brain flow were performed in 11 healthy young volunteers on two separate days applying a strictly standardized setup. For comparison PCM measurements obtained from a previously published study (Dataset 2) were analyzed in order to assess long-term variability in an aged population in a less strictly controlled setup. Global CBF was calculated by normalizing total brain flow to brain volume. On each day measurements of hemoglobin, caffeine and glucose were obtained. Linear m

SUBMITTER: Ismaili ARA 

PROVIDER: S-EPMC5991708 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature