Candidate gene biodosimetry markers of exposure to external ionizing radiation in human blood: A systematic review.

ABSTRACT:

Purpose

To compile a list of genes that have been reported to be affected by external ionizing radiation (IR) and to assess their performance as candidate biomarkers for individual human radiation dosimetry.

Methods

Eligible studies were identified through extensive searches of the online databases from 1978 to 2017. Original English-language publications of microarray studies assessing radiation-induced changes in gene expression levels in human blood after external IR were included. Genes identified in at least half of the selected studies were retained for bio-statistical analysis in order to evaluate their diagnostic ability.

Results

24 studies met the criteria and were included in this study. Radiation-induced expression of 10,170 unique genes was identified and

SUBMITTER: Lacombe J 

PROVIDER: S-EPMC5991767 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature