Stool Immune Profiles Evince Gastrointestinal Inflammation in Parkinson's Disease.

ABSTRACT:

Background

Gastrointestinal symptoms are common in Parkinson's disease and frequently precede the development of motor impairments. Intestinal inflammation has been proposed as a driver of disease pathology, and evaluation of inflammatory mediators in stool could possibly identify valuable early-stage biomarkers. We measured immune- and angiogenesis-related proteins in human stool to examine inflammatory profiles associated with Parkinson's disease.

Methods

Stool samples and subjects' self-reported metadata were obtained from 156 individuals with Parkinson's disease and 110 without, including spouse and nonhousehold controls. Metadata were probed for disease-associated differences, and levels of 37 immune and angiogenesis factors in stool homogenates were measured by multipl

SUBMITTER: Houser MC 

PROVIDER: S-EPMC5992021 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature