Complex karyotype in patients with mantle cell lymphoma predicts inferior survival and poor response to intensive induction therapy.

ABSTRACT: BACKGROUND:Risk stratification of newly diagnosed patients with mantle cell lymphoma (MCL) primarily is based on the MCL International Prognostic Index (MIPI) and Ki-67 proliferative index. Single-center studies have reported inferior outcomes in patients with a complex karyotype (CK), but this remains an area of controversy. METHODS:The authors retrospectively reviewed 483 patients from 5 academic centers in the United States and described the effect of a CK on survival outcomes in individuals with MCL. RESULTS:A CK was found to be associated with inferior overall survival (OS) (4.5 vs 11.6 years; P<.01) and progression-free survival (PFS) (1.9 vs 4.4 years; P<.01). In patients who underwent high-intensity induction followed by autologous stem cell transplantation (ASCT) in first remissio

SUBMITTER: Greenwell IB 

PROVIDER: S-EPMC5992038 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature