Divergent transcriptional profiles in pediatric asthma patients of low and high socioeconomic status.

ABSTRACT: AIM:There are marked socioeconomic disparities in pediatric asthma control, but the molecular origins of these disparities are not well understood. To fill this gap, we performed genome-wide expression profiling of monocytes and T-helper cells from pediatric asthma patients of lower and higher socioeconomic status (SES). METHOD:Ninety-nine children with asthma participated in a cross-sectional assessment. Out of which 87% were atopic, and most had disease of mild (54%) or moderate (29%) severity. Children were from lower-SES (n = 49; household income <$50 000) or higher-SES (n = 50; household income >$140 000) families. Peripheral blood monocytes and T-helper cells were isolated for genome-wide expression profiling of mRNA. RESULTS:Lower-SES children had worse asthma quality of life relati

SUBMITTER: Miller GE 

PROVIDER: S-EPMC5992048 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature