Alternaria alternata challenge at the nasal mucosa results in eosinophilic inflammation and increased susceptibility to influenza virus infection.

ABSTRACT:

Background

Eosinophils in the nasal mucosa are an elemental feature of allergic rhinitis.

Objective

Our objective was to explore eosinophilic inflammation and its impact on respiratory virus infection at the nasal mucosa.

Methods

Inflammation in the nasal mucosae of mice was evaluated in response to repetitive stimulation with strict intranasal volumes of a filtrate of Alternaria alternata. Mice were then challenged with influenza virus.

Results

Repetitive stimulation with A. alternata resulted in eosinophil recruitment to the nasal passages in association with elevated levels of IL-5, IL-13 and eotaxin-1; eosinophil recruitment was diminished in eotaxin-1^-/- mice, and abolished in Rag1^-/- mice. A. alternata also resulted in elevated level

SUBMITTER: Ma M 

PROVIDER: S-EPMC5992052 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature