Ageing effects on humoral immune responses in chronic periodontitis.

ABSTRACT: Periodontal disease is a dominant global bacterial infection that increases with ageing.

Aim

This report focuses on host adaptive immune responses in periodontitis. While experimental models and humans diagnosed with periodontitis demonstrate an antigenic specificity for particular oral bacteria, we have a limited understanding of (i) how ageing affects the adaptive immune responses to these bacteria that chronically colonize the oral cavity for decades prior to disease expression and (ii) how the magnitude and specificity of the response interface with pathogens that emerge within the bacterial ecology during exacerbations of disease.

Materials and methods

Serum antibody levels to a group of pathogenic and commensal oral bacteria were measured in a population of individuals

SUBMITTER: Ebersole JL 

PROVIDER: S-EPMC5992058 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature