Agreement between clinician-rated versus patient-reported outcomes in Huntington disease.

ABSTRACT:

Background

Clinician-rated measures of functioning are often used as primary endpoints in clinical trials and other behavioral research in Huntington disease. As study costs for clinician-rated assessments are not always feasible, there is a question of whether patient self-report of commonly used clinician-rated measures may serve as acceptable alternatives in low risk behavioral trials.

Aim

The purpose of this paper was to determine the level of agreement between self-report and clinician-ratings of commonly used functional assessment measures in Huntington disease.

Design

486 participants with premanifest or manifest Huntington disease were examined. Total Functional Capacity, Functional Assessment, and Independence Scale assessments from the Unified Huntington Dis

SUBMITTER: Carlozzi NE 

PROVIDER: S-EPMC5992091 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature