Molecular characterization and integrative genomic analysis of a panel of newly established penile cancer cell lines.

ABSTRACT: Cell line models are essential tools to study the molecular mechanisms underlying tumor initiation and progression. There are limited treatment options for penile squamous cell carcinoma (PSCC), accounting for 1-2% of male tumors in developing countries, and limited progress in preclinical research in PSCC due to lacking available models with identified genomic characteristics. Here, biological and molecular characteristics and whole-genomic alterations were analyzed in a panel of PSCC cell lines newly established in our laboratory. These cell lines were all human papillomavirus (HPV)-negative, epithelial-like, immortalized, and tumorigenic in nude mice, whereas they displayed different proliferation, migration and invasion capacities in vitro, and tumorigenic ability in nude mice. They we

SUBMITTER: Zhou QH 

PROVIDER: S-EPMC5992159 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature